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Interictal Spikes in Alzheimer’s Disease: Preclinical Evidence for Dominance of the Dentate Gyrus and Cholinergic Control by Medial Septum

2023-04-24

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<h4>ABSTRACT</h4> <h4>HIGHLIGHTS</h4> Interictal spikes (IIS) occur in 3 mouse lines with Alzheimer’s disease features IIS in all 3 mouse lines were most frequent during rapid eye movement (REM) sleep The dentate gyrus showed larger IIS and earlier current sources vs. CA1 or cortex Chemogenetic silencing of medial septum (MS) cholinergic neurons reduced IIS during REM MS silencing did not change REM latency, dur...

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Literature Corpus work
cbdae93a-cb01-5a83-a399-dc51ac5a5c5c
DOI
10.1101/2023.04.24.537999
Open publication

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Interictal Spikes in Alzheimer’s Disease: Preclinical Evidence for Dominance of the Dentate Gyrus and Cholinergic Control by Medial SeptumDOI 10.1101/2023.04.24.537999
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