Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease.

Journal of comparative pathology - 1 May 2017

Finnie G S, Gunnarsson R, Manavis J, Blumbergs P C, Mander K A, Edwards S, Van den Heuvel C, Finnie J W

Abstract excerpt

The spatiotemporal pattern of cerebral amyloid deposition, detectable as light microscopically recognizable aggregates in an 'amyloid only' transgenic mouse model of Alzheimer's disease, B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax, is reported for the first time in this strain. Monoclonal and polyclonal antibodies were used to detect amyloid deposition immunohistochemically in brains collected from these mice at 3-12...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Disease Models, Animal

Share to Mice, Transgenic

Share to Presenilin-1

Source

Identifiers

PMID: 28431735
DOI: 10.1016/j.jcpa.2017.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease.PMID 28431735Read ↗

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer diseaseSemantic proximity Read ↗

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1Semantic proximity Read ↗

Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.Semantic proximity Read ↗

Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathologySemantic proximity Read ↗

Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.Semantic proximity Read ↗

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic miceSemantic proximity Read ↗

Accumulation of murine amyloid-β mimics early Alzheimer’s diseaseSemantic proximity Read ↗

Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse.Semantic proximity Read ↗

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formationSemantic proximity Read ↗

Passive immunization against pyroglutamate-3 amyloid-β reduces plaque burden in Alzheimer-like transgenic mice: a pilot study.Semantic proximity Read ↗

Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.