Article

Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer’s disease in <i>Prnp</i> mutant mice and in the P301S transgenic tauopathy mice model

2024-01-20

Abstract excerpt

The natural cellular prion protein is known to play several roles during development and adult brain. Far from its pathological roles in prionopathies, the non-pathogenic cellular prion protein has been described as a receptor for several amyloid in oligomeric and prefibrillar forms. For some amyloids, specific domains of the protein play a crucial role in modulating amyloid’s cellular uptake and seeding propertie...

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Literature Corpus work: 3eeffc68-1fd8-5f87-920d-0497f78d0d2b
DOI: 10.1101/2024.01.20.576414

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Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer’s disease in <i>Prnp</i> mutant mice and in the P301S transgenic tauopathy mice modelDOI 10.1101/2024.01.20.576414Read

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