Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of prion protein in the brain that is not associated with transmissible disease.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Piccardo Pedro, Manson Jean C, King Declan, Ghetti Bernardino, Barron Rona M

Abstract excerpt

Prion diseases or transmissible spongiform encephalopathies are characterized histopathologically by the accumulation of prion protein (PrP) ranging from diffuse deposits to amyloid plaques. Moreover, pathologic PrP isoforms (PrP(Sc)) are detected by immunoblot analysis and used both as diagnostic markers of disease and as indicators of the presence of infectivity in tissues. It is not known which forms of PrP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Mice, Transgenic

Share to Prion Diseases

Share to Prions

Share to Protein Isoforms

Share to Telencephalon

Source

Open in PubMed Open full text

Identifiers

PMID: 17360589
DOI: 10.1073/pnas.0609241104
PMCID: PMC1838665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of prion protein in the brain that is not associated with transmissible disease.PMID 17360589Read ↗

Genetic and infectious prion diseases.Semantic proximity Read ↗

Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Semantic proximity Read ↗

Transmissibility of Gerstmann-Sträussler-Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity.Semantic proximity Read ↗

Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathy.Semantic proximity Read ↗

Prion encephalopathies of animals and humans.Semantic proximity Read ↗

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.Semantic proximity Read ↗

The role of PrP in health and disease.Semantic proximity Read ↗

Experimental Models of Inherited PrP Prion Diseases.Semantic proximity Read ↗

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.Semantic proximity Read ↗

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions.Semantic proximity Read ↗

Transgenic mice recapitulate the phenotypic heterogeneity of genetic prion diseases without developing prion infectivity: Role of intracellular PrP retention in neurotoxicity.Semantic proximity Read ↗

Prion dementia without characteristic pathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.