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Article

Tau oligomers impair memory and synaptic plasticity through the cellular prion protein

27 Jan 2025

Abstract excerpt

Deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in Alzheimer’s disease (AD) and other tauopathies. Among tau aggregates, oligomers (TauOs) are considered the most toxic. AD brains show significant increase in TauOs compared to healthy controls, their concentration correlating with the severity of cognitive deficits and disease progression. In...

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PMID: 39871396
DOI: 10.1186/s40478-025-01930-3

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