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The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

25 Apr 2013

Abstract excerpt

The misfolding and aggregation of specific proteins is a common hallmark of many neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and Parkinson's diseases, as well as rarer disorders such as Huntington's and prion diseases. Among these, only prion diseases are 'infectious'. By seeding misfolding of the PrP(C) (normal conformer prion protein) into PrP(Sc) (abnormal...

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PMID: 23614720
DOI: 10.1042/bj20121898

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