Article

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies

2021-04-20

Abstract excerpt

The cellular prion protein (PrP C ) is a central player in neurodegenerative diseases caused by protein misfolding, such as prion diseases or Alzheimer’s disease (AD). Expression levels of this GPI-anchored glycoprotein, especially at the neuronal cell surface, critically correlate with various pathomechanistic aspects underlying these diseases, such as templated misfolding (in prion diseases) and neurotoxicity a...

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Literature Corpus work: 90e4cf38-7dab-53f3-9d6a-93aca343093b
DOI: 10.1101/2021.04.19.440495

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