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Article

Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion.

PloS one - 1 Jan 2013

Solis Gonzalo P, Radon Yvonne, Sempou Emily, Jechow Katharina, Stuermer Claudia A O, Málaga-Trillo Edward

Abstract excerpt

Analyses of cultured cells and transgenic mice expressing prion protein (PrP) deletion mutants have revealed that some properties of PrP -such as its ability to misfold, aggregate and trigger neurotoxicity- are controlled by discrete molecular determinants within its protein domains. Although the contributions of these determinants to PrP biosynthesis and turnover are relatively well characterized, it is still...

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PMID: 23936187
DOI: 10.1371/journal.pone.0070327
PMCID: PMC3729945

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