Article

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau

2023-03-28

Abstract excerpt

Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s disease. More recent studies have implicated soluble oligomeric tau species, referred to as high molecular weight (HMW) due to its properties on size exclusion chromatography, in tau propagation across neural systems....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 759f7a15-945c-522d-8510-484285c82ffd
DOI: 10.1101/2023.03.28.534418

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tauDOI 10.1101/2023.03.28.534418Read

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's DiseaseSemantic proximity Read

Conformation Determines the Seeding Potencies of Native and Recombinant Tau AggregatesSemantic proximity Read

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein PathologySemantic proximity Read

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.Semantic proximity Read

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers.Semantic proximity Read

Tau and neurodegeneration.Semantic proximity Read

Tau in the brain interstitial fluid is fragmented and seeding–competentSemantic proximity Read

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.Semantic proximity Read

Fate and propagation of endogenously formed Tau aggregates in neuronal cellsSemantic proximity Read

Biochemical Properties of Pathology-Related Tau Species in Tauopathy Brains: An Extraction Protocol for Tau Oligomers and Aggregates.Semantic proximity Read

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential InhibitorsSemantic proximity Read

Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesiclesSemantic proximity Read