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Environmental exposures and mutational patterns of cancer genomes

1 Jan 2010

Abstract excerpt

The etiology of most human cancers is unknown. Genetic inheritance and environmental factors are thought to have major roles, and for some types of cancer, exposure to carcinogens is a proven mechanism leading to tumorigenesis. Sequencing of entire cancer genomes has not only begun to provide clues regarding functionally relevant mutations, but has also paved the way towards understanding the initial exposures...

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PMID: 20707934
DOI: 10.1186/gm175

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