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Article

Integrated multi-omics characterization of KRAS mutant colorectal cancer.

Theranostics - 1 Jan 2022

Chong Wei, Zhu Xingyu, Ren Huicheng, Ye Chunshui, Xu Kang, Wang Zhe, Jia Shengtao, Shang Liang, Li Leping, Chen Hao

Abstract excerpt

KRAS mutation is the most frequent oncogenic aberration in colorectal cancer (CRC). The molecular mechanism and clinical implications of KRAS mutation in CRC remain unclear and show high heterogeneity within these tumors. Methods: We harnessed the multi-omics data (genomic, transcriptomic, proteomic, and phosphoproteomic etc.) of KRAS-mutant CRC tumors and performed unsupervised clustering to identify...

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Identifiers

PMID: 35836817
DOI: 10.7150/thno.73089
PMCID: PMC9274732

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