Article

Whole-transcriptome RNA editing analysis in single cortical neurons links locus 15q11 with psychiatric illness

2019-11-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Conversion of adenosine to inosine in RNA by ADAR enzymes occurs at thousands of sites in the human transcriptome, and is essential for healthy brain development. This ‘RNA editing’ process is dysregulated in many neuropsychiatric diseases, but is little understood at the level of individual neurons. <h4>METHODS</h4> We quantified RNA editing sites in full-length capture nu...

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Literature Corpus work: 3eab7e22-8e4d-565c-b6b2-0a050d3e77c6
DOI: 10.1101/840892

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