Article
Whole transcriptome RNA-Seq allelic expression in human brain.
BMC genomics - 22 Aug 2013
Smith Ryan M, Webb Amy, Papp Audrey C, Newman Leslie C, Handelman Samuel K, Suhy Adam, Mascarenhas Roshan, Oberdick John, Sadee Wolfgang
Abstract excerpt
BACKGROUND: Measuring allelic RNA expression ratios is a powerful approach for detecting cis-acting regulatory variants, RNA editing, loss of heterozygosity in cancer, copy number variation, and allele-specific epigenetic gene silencing. Whole transcriptome RNA sequencing (RNA-Seq) has emerged as a genome-wide tool for identifying allelic expression imbalance (AEI), but numerous factors bias allelic RNA ratio...
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