Article
Deciphering the functions and regulation of brain-enriched A-to-I RNA editing.
Nature neuroscience - 1 Nov 2013
Li Jin Billy, Church George M
Abstract excerpt
Adenosine-to-inosine (A-to-I) RNA editing, in which genomically encoded adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on RNA (ADAR). This fine-tuning mechanism is critical during normal development and diseases, particularly in relation to brain functions. A-to-I RNA editing has also been hypothesized to be a driving force in human brain evolution. A large number of RNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.