Article

Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease

2025-10-03

Abstract excerpt

Adenosine-to-inosine (A-to-I) RNA editing is among the most abundant post-transcriptional modifications, whose role in homeostasis and disease of the central nervous system (CNS) has been extensively reported. Regulation of A-to-I editing by cis -acting genetic variants (edQTLs) is understudied, especially in the brain. As a part of the BigBrain Project (n=4,471 individuals), which represents a >10-fold increase...

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Literature Corpus work: 2b6de5cc-9ad9-5511-b842-38f1210c188a
DOI: 10.1101/2025.09.30.25337026

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