Article

Investigating novel interaction partners of amyloid precursor protein : the mechanistic target of rapamycin and PIKfyve complex

2016-01-01

Abstract excerpt

Although the amyloid precursor protein (APP) is known to have a central role in Alzheimer's disease, its cellular function is poorly characterised. To better understand the cellular functions of APP, an interactome of APP’s intracellular domain (AICD) was generated using a proteo-lipososome based assay, which enabled interactions to be identified within a membrane context. In addition to proteins known to bind AIC...

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Literature Corpus work: 3e99a9d0-18fb-5880-8e32-080692049787
DOI: 10.48780/publications.aston.ac.uk.00030350

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