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Article

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

2 Jul 2021

Abstract excerpt

Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR). As a nutrient sensor, mTOR has important homeostatic functions to regulate energy metabolism and support neuronal growth and plasticity. However, in Alzheimer's disease (AD), mTOR alternately...

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PMID: 34215308
DOI: 10.1186/s13024-021-00428-5

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