Article

Combined family history and polygenic score prediction of major depressive disorder

2025-09-23

Abstract excerpt

<h4>Importance</h4> Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with distinct contributions. <h4>Objective</h4> This study modelled the combined effects of family history of multiple psychiatric disorders, polygenic scores of multiple t...

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Literature Corpus work: 3e7f16a5-b4ee-5d77-94ee-470424b93a50
DOI: 10.1101/2025.09.22.25336356

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