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Article

The association between trauma exposure, polygenic risk and individual depression symptoms.

Psychiatry research - 1 Mar 2023

Thorp Jackson G, Gerring Zachary F, Colodro-Conde Lucía, Byrne Enda M, Medland Sarah E, Middeldorp Christel M, Derks Eske M

Abstract excerpt

BACKGROUND: Traumatic experiences are associated with increased risk for major depressive disorder (MDD). This study sought to determine the extent that trauma exposure, depression polygenic risk scores (PRS), and their interaction are associated with MDD and individual depression symptoms. METHODS: Data from 102,182 individuals from the large-scale UK Biobank population cohort was analysed. A series of...

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Identifiers

PMID: 36774750
DOI: 10.1016/j.psychres.2023.115101
PMCID: PMC9977888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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