Genome-by-Trauma Exposure Interactions in Adults With Depression in the UK Biobank.

Abstract excerpt

Importance: Self-reported trauma exposure has consistently been found to be a risk factor for major depressive disorder (MDD), and several studies have reported interactions with genetic liability. To date, most studies have examined gene-environment interactions with trauma exposure using genome-wide variants (single-nucleotide variations [SNVs]) or polygenic scores, both typically capturing less than 3% of...

Topics

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• Biological Specimen Banks
• Child
• Cross-Sectional Studies
• Depression
• Depressive Disorder, Major