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Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up.

Molecular psychiatry - 1 Mar 2026

Haram Marit, Jangmo Andreas, Jaholkowski Piotr, Pasman Joëlle, Meijsen Joeri, Shorter John R, Corfield Elizabeth C, Frei Oleksandr, Reichborn-Kjennerud Ted, Buil Alfonso, Lu Yi, Werge Thomas, Sullivan Patrick, Andreassen Ole A, Tesli Martin

Abstract excerpt

Genetic risk could be informative for identifying individuals at risk of depression with severe outcomes. With the novel approach of combined health care registries and self-report measures related to depression, the authors aimed to identify the impact of polygenic risk scores (PRS) for major depression on self report measures and a diagnosis of depression across diagnostic thresholds. The study sample comprised...

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Depression
Genetic Risk Score
Major Depressive Disorder
Norway

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychiatric Status Rating Scales

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PMID: 40962829
DOI: 10.1038/s41380-025-03243-2
PMCID: PMC12916310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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