Article
Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.
Psychological medicine - 1 Aug 2024
Choi Karmel W, Tubbs Justin D, Lee Younga H, He Yixuan, Tsuo Kristin, Yohannes Mary T, Nkambule Lethukuthula L, Madsen Emily, Ghimire Dirgha J, Hermosilla Sabrina, Ge Tian, Martin Alicia R, Axinn William G, Smoller Jordan W
Abstract excerpt
BACKGROUND: Major depressive disorder (MDD) is the leading cause of disability globally, with moderate heritability and well-established socio-environmental risk factors. Genetic studies have been mostly restricted to European settings, with polygenic scores (PGS) demonstrating low portability across diverse global populations. METHODS: This study examines genetic architecture, polygenic prediction, and...
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