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Article

Effect of polygenic risk scores on depression in childhood trauma.

The British journal of psychiatry : the journal of mental science - 1 Aug 2014

Peyrot Wouter J, Milaneschi Yuri, Abdellaoui Abdel, Sullivan Patrick F, Hottenga Jouke J, Boomsma Dorret I, Penninx Brenda W J H

Abstract excerpt

BACKGROUND: Research on gene × environment interaction in major depressive disorder (MDD) has thus far primarily focused on candidate genes, although genetic effects are known to be polygenic. AIMS: To test whether the effect of polygenic risk scores on MDD is moderated by childhood trauma. METHOD: The study sample consisted of 1645 participants with a DSM-IV diagnosis of MDD and 340 screened controls from The...

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Identifiers

PMID: 24925986
DOI: 10.1192/bjp.bp.113.143081
PMCID: PMC4118052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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