Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.

doi:10.1016/j.biopsych.2017.09.009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.

Biological psychiatry - 15 Jul 2018

Peyrot Wouter J, Van der Auwera Sandra, Milaneschi Yuri, Dolan Conor V, Madden Pamela A F, Sullivan Patrick F, Strohmaier Jana, Ripke Stephan, Rietschel Marcella, Nivard Michel G, Mullins Niamh, Montgomery Grant W, Henders Anjali K, Heat Andrew C, Fisher Helen L, Dunn Erin C, Byrne Enda M, Air Tracy A, Baune Bernhard T, Breen Gerome, Levinson Douglas F, Lewis Cathryn M, Martin Nick G, Nelson Elliot N, Boomsma Dorret I, Grabe Hans J, Wray Naomi R, Penninx Brenda W J H

Abstract excerpt

BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child Abuse

Share to Depressive Disorder, Major

Share to Gene-Environment Interaction

Share to Logistic Models

Share to Multifactorial Inheritance

Share to Psychiatric Status Rating Scales

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 29129318
DOI: 10.1016/j.biopsych.2017.09.009
PMCID: PMC5862738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.PMID 29129318Read ↗

Effect of polygenic risk scores on depression in childhood trauma.Semantic proximity Read ↗

The association between trauma exposure, polygenic risk and individual depression symptoms.Semantic proximity Read ↗

Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression.Semantic proximity Read ↗

Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD.Semantic proximity Read ↗

Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters.Semantic proximity Read ↗

Genome-by-Trauma Exposure Interactions in Adults With Depression in the UK Biobank.Semantic proximity Read ↗

Combined family history and polygenic score prediction of major depressive disorderSemantic proximity Read ↗

Identifying genome-by-childhood trauma interactions for depression using a forest-based approach in the UK Biobank and Adolescent Brain Cognitive Development Study.Semantic proximity Read ↗

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.Semantic proximity Read ↗

Interaction between COMT Val158 Met polymorphism and childhood trauma predicts risk for depression in men.Semantic proximity Read ↗

Gene-Environment Correlation Across Trauma Subtypes and Developmental Timing: Evidence From the EU-GEI and ALSPAC.Semantic proximity Read ↗

The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.