Article

Engineering an artificial catch bond using mechanical anisotropy

2023-09-15

Abstract excerpt

Catch bonds are a rare class of protein-protein interactions where the bond lifetime increases under an external pulling force. Here, we report how modification of anchor geometry generates catch bonding behavior for the mechanostable Dockerin G:Cohesin E (DocG:CohE) adhesion complex found on human gut bacteria. Using AFM single-molecule force spectroscopy in combination with bioorthogonal click chemistry, we mech...

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Identifiers and source

Literature Corpus work: 3e65fe0f-b678-551c-b335-2b18f6b35a6f
DOI: 10.1101/2023.09.12.557335

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