Article
Modulation of Mechanical Properties of Short Bioinspired Peptide Materials by Single Amino-Acid Mutations.
Journal of the American Chemical Society - 15 Feb 2023
Hiew Shu Hui, Lu Yang, Han Hao, Gonçalves Rui A, Alfarano Serena Rosa, Mezzenga Raffaele, Parikh Atul N, Mu Yuguang, Miserez Ali
Abstract excerpt
The occurrence of modular peptide repeats in load-bearing (structural) proteins is common in nature, with distinctive peptide sequences that often remain conserved across different phylogenetic lineages. These highly conserved peptide sequences endow specific mechanical properties to the material, such as toughness or elasticity. Here, using bioinformatic tools and phylogenetic analysis, we have identified the...
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