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Article

Calcium-induced strain in the monomer promotes dimerization in neural cadherin.

Biochemistry - 4 Oct 2011

Vunnam Nagamani, Pedigo Susan

Abstract excerpt

Cadherins are cell adhesion proteins that are important for tissue formation and integrity. Cell-cell adhesion occurs through the formation of the strand-crossover dimer between identical cadherins on the surface of neighboring cells. The strand-crossover dimer forms exclusively between their EC1 domains via swapping of the βA sheet by undocking the conserved tryptophan 2, W2, from its own hydrophobic pocket and...

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Identifiers

PMID: 21870846
DOI: 10.1021/bi200902s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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