Article

Force-Activated Slip-Catch-Slip Bonds Stabilize Virus Interactions

2026-03-02

Abstract excerpt

<title>Abstract</title> <p>Viral adhesion often relies on dynamic molecular interactions that adapt to mechanical stress. Here, we report that SARS-CoV-2 spike proteins form catch bonds with the human ACE2 receptor, whereby moderate tensile forces enhance bond lifetimes before yielding at higher loads. Using single-molecule atomic force spectroscopy, we quantitatively resolved these nonmonotonic force–lifetime re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d493d872-771f-5ba4-92e7-41c478f424ea
DOI: 10.21203/rs.3.rs-8797158/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Force-Activated Slip-Catch-Slip Bonds Stabilize Virus InteractionsDOI 10.21203/rs.3.rs-8797158/v1Read

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule levelSemantic proximity Read

Pathogen-Host Adhesion between SARS-CoV-2 Spike Proteins from Different Variants and Human ACE2 Probed at Single-Molecule and Single-Cell LevelsSemantic proximity Read

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2.Semantic proximity Read

Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levels.Semantic proximity Read

A Tethered Ligand Assay to Probe the SARS-CoV-2 ACE2 Interaction under Constant ForceSemantic proximity Read

A Tethered Ligand Assay to Probe SARS-CoV-2:ACE2 InteractionsSemantic proximity Read

Single-molecule force stability of the SARS-CoV-2-ACE2 interface in variants-of-concern.Semantic proximity Read

Adsorption-Driven Deformation and Footprints of the RBD Proteins in SARS-CoV-2 Variants on Biological and Inanimate Surfaces.Semantic proximity Read

Single-Molecule Analysis of Human Immunodeficiency Virus Type 1 gp120-Receptor Interactions in Living CellsSemantic proximity Read

Nanoscopic Assessment of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFMSemantic proximity Read

Engineering an artificial catch bond using mechanical anisotropySemantic proximity Read

A comparative nanomechanical study of antibody and nanobody binding to SARS-CoV-2 variants.Semantic proximity Read