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Article

Propagation of pathology through brain networks in neurodegenerative diseases: from molecules to clinical phenotypes.

CNS neuroscience & therapeutics - 1 Oct 2015

Agosta Federica, Weiler Marina, Filippi Massimo

Abstract excerpt

The cellular mechanisms underlying the stereotypical progression of pathology in neurodegenerative diseases are incompletely understood, but increasing evidence indicates that misfolded protein aggregates can spread by a self-perpetuating neuron-to-neuron transmission. Novel neuroimaging techniques can help elucidating how these disorders spread across brain networks. Recent knowledge from structural and...

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PMID: 26031656
DOI: 10.1111/cns.12410
PMCID: PMC6493163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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