Article

Interleukin-1 receptor antagonist mediates type I interferon-driven susceptibility to <i>Mycobacterium tuberculosis</i>

2018-08-10

Abstract excerpt

The bacterium Mycobacterium tuberculosis ( Mtb ) causes tuberculosis (TB) and is responsible for more human mortality than any other single pathogen 1 . Although ~1.7 billion people are infected with Mtb 2 , most infections are asymptomatic. Progression to active disease occurs in ~10% of infected individuals and is predicted by an elevated type I interferon (IFN) response 3–8 . Type I IFNs are vital for anti...

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Literature Corpus work: 3e54850e-8d84-529f-8014-7c05eb7a1915
DOI: 10.1101/389288

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