Article
Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene.
Current topics in microbiology and immunology - 1 Jan 2008
Kramnik I
Abstract excerpt
Genetic variation of the host significantly contributes to dramatic differences in the outcomes of natural infection with virulent Mycobacterium tuberculosis (MTB) in humans, as well as in experimental animal models. Host resistance to tuberculosis is a complex multifactorial genetic trait in which many genetic polymorphisms contribute to the phenotype, while their individual contributions are influenced by...
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