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Article

Ipr1 gene mediates innate immunity to tuberculosis.

Nature - 7 Apr 2005

Pan Hui, Yan Bo-Shiun, Rojas Mauricio, Shebzukhov Yuriy V, Zhou Hongwei, Kobzik Lester, Higgins Darren E, Daly Mark J, Bloom Barry R, Kramnik Igor

Abstract excerpt

An estimated eight million people are infected each year with the pathogen Mycobacterium tuberculosis, and more than two million die annually. Yet only about 10% of those infected develop tuberculosis. Genetic variation within host populations is known to be significant in humans and animals, but the nature of genetic control of host resistance to tuberculosis remains poorly understood. Previously we mapped a new...

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Identifiers

PMID: 15815631
DOI: 10.1038/nature03419
PMCID: PMC1388092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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