Computational analysis of SULT1A1 allozymes reveals potential mechanisms of inter-individual variability in (poly)phenol metabolism

Abstract excerpt

Inter-individual variability in (poly)phenol metabolism can significantly influence health effects, yet its mechanisms are poorly understood. Through a validated multi-tiered computational workflow, this study explored how a single nucleotide polymorphism (SNP) in the SULT1A1 gene (SULT1A1-F247L, forming SULT1A1*5 allozyme) might influence the sulfation of 20 dietary (poly)phenols. The methodological approach comb...

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• Fatty Acid Research and Health
• Phytoestrogen effects and research

Identifiers and source

Literature Corpus work

3e53fe4e-e029-5c42-9ce7-1665cb7d3a80

DOI

10.1038/s41598-026-65193-1