Article

Computational analysis of SULT1A1 allozymes reveals potential mechanisms of inter-individual variability in (poly)phenol metabolism

2026-08-25

Abstract excerpt

Inter-individual variability in (poly)phenol metabolism can significantly influence health effects, yet its mechanisms are poorly understood. Through a validated multi-tiered computational workflow, this study explored how a single nucleotide polymorphism (SNP) in the SULT1A1 gene (SULT1A1-F247L, forming SULT1A1*5 allozyme) might influence the sulfation of 20 dietary (poly)phenols. The methodological approach comb...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e53fe4e-e029-5c42-9ce7-1665cb7d3a80
DOI: 10.1038/s41598-026-65193-1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Computational analysis of SULT1A1 allozymes reveals potential mechanisms of inter-individual variability in (poly)phenol metabolismDOI 10.1038/s41598-026-65193-1Read

The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review.Semantic proximity Read

Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.Semantic proximity Read

Mechanistic insights into dietary (poly)phenols and vascular dysfunction-related diseases using multi-omics and integrative approaches: Machine learning as a next challenge in nutrition researchSemantic proximity Read

Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1.Semantic proximity Read

Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations.Semantic proximity Read

The molecular basis for the broad substrate specificity of human sulfotransferase 1A1.Semantic proximity Read

Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype.Semantic proximity Read

Sulfotransferase 1A1 as a Biomarker for Susceptibility to Carcinogenesis: From Molecular Genetics to the Role of Dietary Flavonoids.Semantic proximity Read

Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.Semantic proximity Read

SULT genetic polymorphisms: physiological, pharmacological and clinical implications.Semantic proximity Read

Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation.Semantic proximity Read

Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health.Semantic proximity Read