Article
The molecular basis for the broad substrate specificity of human sulfotransferase 1A1.
PloS one - 1 Jan 2011
Berger Ilana, Guttman Chen, Amar Dotan, Zarivach Raz, Aharoni Amir
Abstract excerpt
Cytosolic sulfotransferases (SULTs) are mammalian enzymes that detoxify a wide variety of chemicals through the addition of a sulfate group. Despite extensive research, the molecular basis for the broad specificity of SULTs is still not understood. Here, structural, protein engineering and kinetic approaches were employed to obtain deep understanding of the molecular basis for the broad specificity, catalytic...
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