Article
SULT genetic polymorphisms: physiological, pharmacological and clinical implications.
Expert opinion on drug metabolism & toxicology - 1 Jul 2021
Kurogi Katsuhisa, Rasool Mohammed I, Alherz Fatemah A, El Daibani Amal A, Bairam Ahsan F, Abunnaja Maryam S, Yasuda Shin, Wilson Lauren J, Hui Ying, Liu Ming-Cheh
Abstract excerpt
INTRODUCTION: Cytosolic sulfotransferases (SULTs)-mediated sulfation is critically involved in the metabolism of key endogenous compounds, such as catecholamines and thyroid/steroid hormones, as well as a variety of drugs and other xenobiotics. Studies performed in the past three decades have yielded a good understanding about the enzymology of the SULTs and their structural biology, phylogenetic relationships,...
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