Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations.

doi:10.1016/s0006-2952(99)00145-8

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Article

Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations.

Biochemical pharmacology - 15 Aug 1999

Raftogianis R B, Wood T C, Weinshilboum R M

Abstract excerpt

Phenol sulfotransferases (PSTs or phenol SULTs) catalyze the sulfate conjugation of phenolic drugs, xenobiotics, and monoamines. Two human PST isoforms have been defined biochemically, a thermostable (TS), or phenol-preferring, and a thermolabile (TL), or monoamine-preferring form. Pharmacogenetic studies showed that levels of both TS PST activity and TS PST thermal stability (an indirect measure of variation in...

Topics

Animals
Arylsulfotransferase
Base Sequence
COS Cells
Cloning, Molecular
Genotype
Humans
Isoenzymes
Liver
Molecular Sequence Data
Phenotype
Polymorphism, Genetic
Sequence Homology, Nucleic Acid

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Identifiers

PMID: 10413297
DOI: 10.1016/s0006-2952(99)00145-8

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