Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.

doi:10.3390/ijms20246256

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Article

Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.

International journal of molecular sciences - 11 Dec 2019

Dash Raju, Ali Md Chayan, Dash Nayan, Azad Md Abul Kalam, Hosen S M Zahid, Hannan Md Abdul, Moon Il Soo

Abstract excerpt

Sulfotransferase 1A1 (SULT1A1) is responsible for catalyzing various types of endogenous and exogenous compounds. Accumulating data indicates that the polymorphism rs9282861 (R213H) is responsible for inefficient enzymatic activity and associated with cancer progression. To characterize the detailed functional consequences of this mutation behind the loss-of-function of SULT1A1, the present study deployed...

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PMID: 31835852
DOI: 10.3390/ijms20246256
PMCID: PMC6969939

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