Article

Palmitoylation induced activation of SMAD3 exacerbates colitis by promoting TRM cells differentiation

2025-10-23

Abstract excerpt

<title>Abstract</title> <p>Tissue-resident memory T cells (TRM cells) have been shown to play an instrumental role in driving the onset and relapse of inflammatory bowel diseases (IBD). However, the underlying mechanism of TRM cells differentiation and its regulation in intestines remain to be unveiled. Mothers against decapentaplegic homolog 3 (SMAD3) is translocated from nucleus to membrane and activated in res...

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Literature Corpus work: 3e46ec74-47a3-581a-bf2c-6fc76a3ac421
DOI: 10.21203/rs.3.rs-7804610/v1

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