Article

N-methyladenosine-modified PIAS1 promotes microglia polarization to M1 by regulating PPARγ SUMOylation in Inflammatory Bowel Disease-associated hyperalgesia

2023-09-09

Abstract excerpt

<title>Abstract</title><p>Background and Aims: Large number of nociceptive signals produced by intestinal inflammation are transmitted to the spinal dorsal horn, leading to microglia polarization, which is of great significance in mediating central sensitization. Emerging evidence indicate that m6A modification regulates a dynamic macrophage polarization. However, it remains unsolved to link polarization of microg...

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Literature Corpus work: b67a5f87-e9f7-510f-8732-e4aaf7f55bcb
DOI: 10.21203/rs.3.rs-3306886/v1

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