MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.

doi:10.1073/pnas.1501752112

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Article

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Lahiri Amit, Hedl Matija, Abraham Clara

Abstract excerpt

Inflammatory bowel disease (IBD) is characterized by dysregulated host:microbial interactions and cytokine production. Host pattern recognition receptors (PRRs) are critical in regulating these interactions. Multiple genetic loci are associated with IBD, but altered functions for most, including in the rs713875 MTMR3/HORMAD2/LIF/OSM region, are unknown. We identified a previously undefined role for...

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Identifiers

PMID: 26240347
DOI: 10.1073/pnas.1501752112
PMCID: PMC4547281

Genes

MTMR3
HORMAD2
LIF
OSM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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