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Article

Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice.

Free radical biology & medicine - 16 Aug 2025

You Mengyue, Zhang Yun, Gao Meilin, Zhao Wei, Wei Li, Ruan Xiong Z, Chen Yaxi

Abstract excerpt

Metaflammation is characteristic of chronic metabolic inflammation, associated with increased risk of development of metabolic dysfunction-associated steatotic liver disease (MASLD). Palmitoylation of Myeloid differentiation factor 88 (MyD88) adaptor protein mediates biologically important signal transduction pathways in inflammatory responses. However, the molecular mechanisms underlying MyD88 palmitoylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40409695
DOI: 10.1016/j.freeradbiomed.2025.05.403

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