Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in mice

20 Mar 2024

Abstract excerpt

The enzymatic core component of m6A writer complex, Mettl3, plays a crucial role in facilitating the development and progress of gastric and colorectal cancer (CRC). However, its underlying mechanism in regulating intestinal inflammation remains unclear and poorly investigated. First, the characteristics of Mettl3 expression in inflammatory bowel diseases (IBD) patients were examined. Afterward, we generated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to RNA modifications and cancer
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38507548
DOI: 10.1093/cei/uxae025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in micePMID 38507548Read ↗

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal HomeostasisSemantic proximity Read ↗

The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 bindingSemantic proximity Read ↗

S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiencySemantic proximity Read ↗

Epigenetic modification of m6A methylation: Regulatory factors, functions and mechanism in inflammatory bowel disease.Semantic proximity Read ↗

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective AutophagySemantic proximity Read ↗

Identification of an at-risk subpopulation with high immune infiltration based on the peroxisome pathway and TIM3 in colorectal cancerSemantic proximity Read ↗

Single cell transcriptome sequencing indicates the cellular heterogeneity of small intestine tissue in celiac diseaseSemantic proximity Read ↗

Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in miceSemantic proximity Read ↗

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.Semantic proximity Read ↗

TL1A overexpression in Crohn’s Disease and mice alters Paneth cells and microbiota promoting ileal inflammationSemantic proximity Read ↗

OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in the gutSemantic proximity Read ↗

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.