Article

NLRP3 Cys126 palmitoylation by ZDHHC7 Promotes Inflammasome Activation

2023-11-08

Abstract excerpt

NACHT-, leucine-rich-repeat- (LRR), and pyrin domain-containing protein 3 (NLRP3) mediates inflammasome activation in response to multiple pathogen and damage-associated molecular patterns in macrophages. Hyperactivation of NLRP3 inflammasome contributes to many human chronic inflammatory diseases. Understanding how NLRP3 inflammasome is regulated can potentially provide new strategies to treat inflammatory diseas...

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Literature Corpus work: 0f257e72-789a-59a6-a8fc-4c18bcf4f2d4
DOI: 10.1101/2023.11.07.566005

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