Article

DHHC3 mediated Cadm4 palmitoylation regulates myelination in CNS

2022-09-23

Abstract excerpt

Cell adhesion molecule 4 (Cadm4) plays important roles on plasma membrane (PM) to regulate myelin formation and the downregulation of Cadm4 is a prominent feature in many demyelination diseases. However, how Cadm4 maintains its level on PM has been elusive. Here, we identify that Cadm4 is palmitoylated at cysteine-347 (C347) and palmitoylation regulates the stable localization of Cadm4 on PM, as blocking palmitoyl...

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Literature Corpus work: 3b67fb72-0a9b-5f03-81f4-0c92b2914e68
DOI: 10.1101/2022.09.23.509146

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