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Article

Domains of Frailty as Early Risk Factors for Alzheimer’s Disease – Genetic and Causal Evidence

2025-09-19

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is a leading cause of disability and dependency in older adults. Frailty is a phenotypic risk factor for AD, but its causal role remains unclear – partly due to reliance on composite scores that may obscure distinct mechanisms. <h4>Methods</h4> We applied a Mendelian randomisation (MR) framework using two large GWAS of clinically diagnosed AD. Frailty exposures were d...

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Literature Corpus work
3e3cdafe-baaf-5b39-9613-8cafe7e5f131
DOI
10.1101/2025.09.17.25336027
Open publication

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Domains of Frailty as Early Risk Factors for Alzheimer’s Disease – Genetic and Causal EvidenceDOI 10.1101/2025.09.17.25336027
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