Article
A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways.
GeroScience - 1 Aug 2023
Ye Yixuan, Noche Rommell B, Szejko Natalia, Both Cameron P, Acosta Julian N, Leasure Audrey C, Brown Stacy C, Sheth Kevin N, Gill Thomas M, Zhao Hongyu, Falcone Guido J
Abstract excerpt
Frailty is an aging-related clinical phenotype defined as a state in which there is an increase in a person's vulnerability for dependency and/or mortality when exposed to a stressor. While underlying mechanisms leading to the occurrence of frailty are complex, the importance of genetic factors has not been fully investigated. We conducted a large-scale genome-wide association study (GWAS) of frailty, as defined...
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