Article

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling

2024-07-24

Abstract excerpt

Frailty is a multifaceted clinical state associated with accelerated aging and adverse health outcomes. Informed etiological models of frailty hold promise for producing widespread health improvements across the aging population. Frailty is currently measured using aggregate scores, which obscure etiological pathways that are only relevant to subcomponents of frailty. Therefore, we performed the first multivariate...

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Literature Corpus work: ca794195-9e4f-53a0-aa21-eae4f3fbe235
DOI: 10.1101/2024.07.24.24310923

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