Article

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure

2018-02-15

Abstract excerpt

Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the effects of brain cellular composition are often ignored in high-throughput molecular studies. We developed and optimized a cell-type specific expression reference panel and employed digital deconvolution methods to determine brain cellular distribution in three independent transcriptomic studies. We fou...

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Literature Corpus work: 390a8154-47a2-59d7-a424-122e06126e1d
DOI: 10.1101/266296

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