Article
A pan-cancer transcriptome analysis of exitron splicing identifies novel cancer driver genes and neoepitopes.
Molecular cell - 20 May 2021
Wang Ting-You, Liu Qi, Ren Yanan, Alam Sk Kayum, Wang Li, Zhu Zhu, Hoeppner Luke H, Dehm Scott M, Cao Qi, Yang Rendong
Abstract excerpt
Exitron splicing (EIS) creates a cryptic intron (called an exitron) within a protein-coding exon to increase proteome diversity. EIS is poorly characterized, but emerging evidence suggests a role for EIS in cancer. Through a systematic investigation of EIS across 33 cancers from 9,599 tumor transcriptomes, we discovered that EIS affected 63% of human coding genes and that 95% of those events were tumor specific....
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