Article

Actin dysregulation induces immune evasion via oxidative stress-activated PD-L1 in gastric cancer

2024-12-20

Abstract excerpt

Diffuse gastric adenocarcinoma (DGAC) is an aggressive malignancy with limited therapeutic options, poor prognosis, and poorly understood biology. CRACD, an actin polymerization regulator, is often inactivated in gastric cancer, including DGAC. We found that genetic engineering of murine gastric organoids with Cracd ablation combined with Kras mutation and Trp53 loss induced aberrant cell plasticity, hyperproli...

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Literature Corpus work: 3e15d5a4-b7ca-5ac2-b0b9-7f8227cb504e
DOI: 10.1101/2024.12.18.629227

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